论文发表及专利申请情况（近5年，时间倒叙）

一)发表论文和专利情况

1.Yuan Yu, Shuqing Wang, Yaqi Wang, Qianyi Zhang, Lina Zhao, Yang Wang, Jinghua Wu, Liyuan Han, Junli Wang, Jimin Guo, Jiarui Xue, Fenglin Dong, Jing Hua Zhang*, Liu Zhang, Yan Liu*, Guogang Shi, Xiaojun Zhang, Yufeng Li, Jingwu Li. AKT1 Promotes Tumorigenesis and Metastasis by Directly Phosphorylating Hexokinases. 2024 Jun 11. doi: 10.1002/jcb.30613

2.Yan Liu, Junli Wang, Jimin Guo, Qianyi Zhang, Shuqing Wang, Fen Hu, Jinghua Wu, Yating Zhao, Jinghua Zhang*, Yuan Yu*, Yufeng Li*, Xiaojun Zhang*. Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer. Scientific reports. 2024 Mar 04;14(1):5228. doi:10.1038/s41598-024-56073-7

3.Qingke Li#, Zhiwu Wang#, Jian Wang, Jiangong Wang, Xuan Zheng, Dan Li, Zhuo Wang, Jingwu Li*, Yufeng Li*. Regulatory feedback loop between circ-EIF4A3 and EIF4A3 enhances autophagy and growth in colorectal cancer cells. Transl Oncol. 2024 May 24:46:101996.

4.Ying Liu#; Yufeng Li#; Li Chen#; Weina Zha; Jing Zhang; Kun Wang; Chunhai Hao; Jianhe Gan. Construction of an Oxidative Stress Risk Model to Analyze the Correlation Between Liver Cancer and Tumor Immunity. Current Cancer Drug Targets, 2024, 24. 

5.Guo Jimin, Xue Jiarui, Dong Fenglin, Zhao Lina, Wang Shuqing, Liu Yan. Analysis of the Co-Pro-Cancer Mechanism of BAZ1A and BAZ2A in Cervical Cancer. the journal of reproductive medicine, 2024,67(2):510-517.　

6.Yuhui Li#, Xuan Zheng#, Dan Li, Mingyang Sun, Zhuo Wang, Jingwu Li* and Yufeng Li*. Facilitation of Temozolomide Resistance of Glioblastoma by Long Noncoding RNA DLK1-35. Iranian Red Crescent Medical Journal. 2023 May; 25(5):e2468.

    7.Yuhui Li#, Xuan Zheng#, Jangong Wang, Mingyang Sun, Dan Li, Zhuo Wang, Jingwu Li*, Yufeng Li*, Yongliang Liu*. Exosomal circ-AHCY promotes glioblastoma cell growth via Wnt/β-catenin signaling pathway. Ann Clin Transl Neurol. 2023 Jun;10(6):865-878.

    8.Shuqing Wang#, Yufeng Li#, Yudong Zhang, Dan Li, Zhuo Wang, Yanrong Zhang, Ning Zhang, Jinghua Zhang*. Effect of JMJD6 and EYA2 on modulating radio-resistance of breast cancer cells. International Journal of Human Genentics. 2023, 23(1):75-84.

    9.Yuhui Li#, Dan Li#, Yankun Liu, Shuqing Wang, Mingyang Sun, Zhongyuan Zhang, Xuan Zheng, Jingwu Li*, Yufeng Li*. The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAFV600E mutation contributes to tumorigenesis and development of glioblastoma. BBRC. 2022 Jan 15;588:1-7.

10.Cao X K,Ma Q H,Wang B,Qian Q Q,Xi Y N.Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation.[J] Ann N Y Acad Sci. 2021.

11.Qian Q Z,Ma Q H,Wang B,Qian Q Q,Zhao C S,Feng F M,Dong X N.MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination[ J ]Cell Mol Med.2021.

12.Wang p,Zhao X Q,Wu X T,Tang G S,Yuan L N.miR-15b-3p promotes the malignant progression of endometrial cancer cells through targeting KLF2[J] Cell Cycle.2021.20(14).1431-1440.

13.Xiong w,Huang X Z,Yao S H,Wang L Q,Wang J,Wang X H.Expression of AKR1C3,beta-Catenin and LEE1in Esophageal Squamous Call Carcinoma and the Relationship with Radiation Resistance[J] Iran J Public Health.2021,50(7).1488-1490

14.Zhang S L,Wang Y Q,Zhang J H,Hu J W,Ma J,Gu Z,Wang Y,Chen J J.Methylated p16 gene is associated with negative expression of estrogen receptor progesterone receptor and human epidermal growth factor receptor 2 in breast cancer[J] J Cancer Res Ther.2021,42(3),530-536

15.Li Y H,Zhou Y,Liu Y Y,Zhang G J,Xiao L,Li N,Qin H F,Wang J G,Zhang L.Severe immune-related hyperthermia followed by immune-related pneumonitis with PD-1 inhibitor (sintilimab) in small cell lung cancer:A case report[J] Case Reports.2021,12(11),1780-1783.

16.Xiong W,nHuang X Z,Hue W N.AKR1C3 and beta-catenin expression in non-small cell lung cancer and relationship with radiation resistance[J] J BUON.2021,26(3),802-811.

17.Zhang S Y,Ding X G,Miao H X,Wang L,Xian L G,Han S G,Zhang D,Li J.The Effects of MIR-320 on the Proliferation and Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells.2021,11(5),937-942.

18.Dai S,Huang Y,Liu T,Xu Z H,Liu T,Chen L,Wang Z W,Lou F.Development and validation of RNA binding protein-applied prediction model for gastric cancer[J]Aging(Albany NY).2021,13(4),5539-5552.

19.Zhao F C,Wang Z Y,Gao Y L,Wu Y S,Liu J M,He S L.Randomized Efficacy Trial of Conventional,TCM Herb,and TEAS onBone Marrow Suppression in Patients with Small Cell Lung Cancer after lnitial Chemotherapy[J] Evid Based Complement Alternat Med.2021,2021

20.Dong W Y,An B,Wang Y,CuiX Y,Gan J H.Effect of multimodal analgesia on gynecological cancer patients after radical resection[J] Am J Transl Res.2021,13(4)2686-2693.

21.Zhao J,Chai G Z,Yang F J,Xu L Z,Zhao J,Wang Y P,Liu C Y.Analysis of the change of clinical nursing pathway in health education among patients with ovarian carcinoma[J] Am J Transl Res.2021,13(4),3138-3146.

22.Dong W,Li J W,Dong X L,Shi W J,Zhang Y,Liu Y L.MiR-17 and miR-93Promote Tumor Progressio by Targeting p21 in Patients with Chordoma[J] Onco Targets Ther.2021,14,3109-3118.

23.Li Q K, Chen J, Hu Y, H?ti N, Lih TM, Thomas SN, Chen L, Roy S, Meeker A, Shah P, Chen L, Bova GS, Zhang B, Zhang H. Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors. Sci Rep[J] Sci Rep. 2021 Sep 23;11(1):18936.

24.Wang J#, Liu Y T#, Li Y, Zheng X, Gan J H, Wan Z Y, Zhang J, Liu Y, Wang Y Q, Hu W N*, Li Y F*, Liu Y K* Exosomal-miR-10a Derived from Colorectal Cancer Cells Suppresses Migration of Human Lung Fibroblasts and Expression of IL-6, IL-8 and IL-1β[J]. Molecular Medicine Reports. 2020 Accepted.

25.Liu Y, Zhang Y Y, Wang S Q, Li M, Long Y H, Li Y F*, Liu Y K, Li Y H, Wang Y Q, Mi J S, Yu C H, Li D Y, Zhang J H*, Zhang X J*. WSTF acetylation by MOF promotes WSTF activities and oncogenic functions[J]. Oncogene. 2020(39):5056-5067.

26.Liu Y, Long Y H, Wang S Q, Zhang Y Y, Li Y F, Mi J S, Yu C H, Li D Y, Zhang J H*, Zhang X Z*. JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity[J]. Oncogene. 2019,38(7):980-997.

27.Xiao J#, Liu Y K#, Wu F X #,Liu R Y#, Xie Y L, Yang Q, Li Y F, Liu M, Li S P, Tang H*. miR-639 Expression Is Silenced by DNMT3AMediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells[J]. Molecular Therapy. 2020 Feb 5;28(2):587-598.

28.Hu Y, Wu F X, Liu Y K, Zhao Q, Tang H*. DNMT1 Recruited by EZH2-mediated Silencing of miR-484 Contributes to the Malignancy of Cervical Cancer Cells Through MMP14 and HNF1A[J]. Clinical Epigenetics. 2019,11:186.

29.Yao L L, Zhou Y D, Sui Z H, Zhang Y L, Liu Y K, Xie H, Gao H J, Fan H X, Zhang Y, Liu M, Li S P, and Tang H. HBV-encoded miR-2 functions as an oncogene by downregulating TRIM35 but upregulating RAN in liver cancer cells[J]. EBioMedicine. 2019 Oct;48:117-129.

30.Liu Y, Long Y H, Wang S Q, Zhang Y Y, Li Y F, Mi J S, Yu C H, Li D Y, Zhang* J H, Zhang* X J. JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity[J]. Oncogene, 2018, 38(7):980-997.

31.Li Y F, Dong W Y, Shan X J, Hong H, Liu Y, Liu Y K, Liu S H, Zhang* X J, Zhang* J H. Anti-tumor effects of Mfn2 in breast cancer are promoter DNA methylation, P21Ras binding site and PKA phosphorylation site dependent[J]. Oncology Letters, 2018, 15(5):8011-8018.

32.Dong W, Li J, Liu Q, Liu C, Li C, Song G, Zhu H, Gao H, Zhang Y. P21waf1/cip1 and p27kip1 are correlated with the development and invasion of prolactinoma[J]. Journal of Neuro-Oncology, 2018, 136(3):485-494.

33.Liu M Y, Zhang Y, Zhang J, Cai H, Zhang C, Yang Z, Niu Y, Wang H, Wei X, Wang W, Gao P, Li H, Zhang J H, Sun G H. MicroRNA-1253 suppresses cellproliferation and invasion of non-small-celllung carcinoma by targeting WNT5A[J]. Cell Death and Disease, 2018, 9(2):189.

34.He X, Chen S Y, Yang Z, Zhang J, Wang W, Liu M Y, Niu Y, Wei X M, Li H M, Sun G G, Hu W N, Sun G H. miR-4317suooresses non-snall cell lung cancer (NSCLC)bytargeting fibroblast growth factor 9(FGF9)and cyclin D2(CCND2)[J]. Journal of Experimental and Clinical Cancer Research, 2018, 37(1):230.

35.Liu Y K, Zhanq Y N, Wu H D, Li Y F, Zhang Y, Liu M, Li X, Tang* H. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis[J]. Cell Death and Disease, 2017, 8(4):e2739.

36.Liu Y K, Han S G, Li Y H, Liu Y, Zhang D, Li* Y F, Zhang* J H. miR-20a contributes to cisplatin-resistance and migration of ovarian cancer cell line OVCAR3[J]. Oncology Letters, 2017, 14(2):1780-1786.

37.Nagarajan D, Wang L, Zhao W, Han X. Trichostatin A inhibits radiation-induced epithelial-tomesenchymal transition in the alveolar epithelial cells[J]. Oncotarget, 2017, 8(60):101745-101759.

38.Zhao Y, He J, Sun G G, Hu W. miR-769-5p suppressed cell proliferation,migration and inwasion by targeting TGFBR1 in non-small cell lung carcinoma[J]. OncotargetYang Z, He J, Gao P. miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma[J]. Oncotarget, 2017, 8(69):113558-113570.

39.Xu S, Tian S, Jiang C, Liu X, Zhang Z, Chen H, Zhang Y, Liu Y, Ma D. Hypermethylation of IFN-γ in oral cancer tissues[J]. Clinical Oral Investigations, 2017, 21(8):2535-2542.

40.Gan J H, Zhao Z Y, Liu J B, Cheng Q. Clinical evaluation of combination of dexmedetomidine and midazolam vs. dexmedetomidine alone for sedation during spinal anesthesia[J]. Saudi Journal of Biological Sciences, 2017, 24(8):1758-1762.

41.Zheng M, Zhou S, Shen Y, Wang L, Che R, Hu W, Li P. DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer[J]. Oncotarget, 2017, 8(21):34652-34660.

42.Zheng M, Hu W, Gao H, Sun S, Wang H, Yue Z, Zhu Y, Han X, Yang J, Zhou Y, Cai Y. Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer[J]. Oncotarget, 2017, 8(38):64170-64179.

43.Zhao Y T, Yan J Y, Han X C, Niu F L, Zhang J H, Hu W N. Anti-proliferative effect of digoxin on breast cancer cells via inducing apoptosis[J]. European Review for Medical and Pharmacological Sciences, 2017, 21(24):5837-5842.

44.Zhang Y, Yan J Y, Wang L, Dai H, Li N, Hu W, Cai H F. HIF-1a Promotes Breast Cancer Cell MCF-7 Proliferationand Invasion Through Regulating miR-210[J]. Cancer Biotherapy and Radiopharmaceuticals, 2017, 32(8):297-301.

45.Yan J Y, Cai H F, Zhang J H, Zhang B, Li N, Hu W N. Treatment of breast cancer based on FOLFOX4 therapy for colon cancer: A case report[J]. Biomedical Research, 2017, 258-261.

46.Zhang J H, Zhang T, Gao S H, Wang K, Yang X Y, Mo F F, Yu N, An T, Li Y F, Hu J W, Jiang* G J. Mitofusin-2 is required for mouse oocyte meiotic maturation, 2016, 6(1):30970.

47.Zhang Y, Wang L, Li N, Dai H, Sun J, Cai H F. Downregulation of long non-coding RNA MALAT1 induces tumor progression of human breast cancer through regulating CCND1 expression[J]. Open Life Sciences, 2016, 11: 232–236.

48.Yan J Y, Zhang Y. The role of miR-222 and miR-298 in breast cancer drug resistance[J]. International Journal of Clinical and Experimental Pathology, 2016, 9(10):9931-9937.

49.Liu Y K, Guo S H, Wang L, Suzuki S, Sugimura H, Li Y F. Uterien Angiosarcoma :A Case Report and Literature Review [J]. International journal of Gynecological Pathology, 2016, 35(3):264-8.

50.Liu X, Guan Y, Xu S, Li Q, Sun Y, Han R, Jiang C. Early Predictors of Acute Kidney Injury:A Narrative Review [J]. Kidney Blood Pressure Research, 2016, 41(5):680-700.

51.Song H, Xiong H, Che J, Xi Q S, Huang L, Xiong H H.Gel-Based Chemical Cross-Linking Analysis of 20S Proteasome Subunit-Subunit Interactions in Brest Cancer [J]. J Huazhong University Science Technology Medical Science, 2016, 36(4):564-570.

52.Zhao L M, Sun G G, Han L N, Liu L H, Ren F Z, Li L, Ma M, Shan B E. P-Hydroxycinnamaldehyde Induces B16-F1 Mwlanoma cell Differentiation via the RhoA-MAPK Signaling pathway [J]. Cellular Physiolgy and Biochemistry, 2016, 38(6):2247-60.

53.Zhang J H, Zhang T, Gao S H, Wang K, Yang X Y, Mo F F, Na Yu, An T, Li Y F, Hu J W, Jiang G J. Mitofusin-2 is required for mouse oocyte meiotic maturation [J]. Scientific Reports, 2016 , 6:30970.

54. Wang Y, Liu Y, Li Y, Zhang J, Liu Y, Li Y, Deng Y, Wang S. Williams syndrome transcription factor is a target of pro-oncogenic Ser158 phosphorylation mediated by Ras-MAPK pathway in human breast cancer [J]. International Journal of Clinical and Experimental Pathology, 2016, 9(2), 1668-1675.

55.Liu Y, Wang S Q, Long Y H, Chen S, Li Y F, Zhang J H. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway [J]. Oncotarget, 2016, 7(33):53153-53164.

56.Liu Y, Long Y H, Wang S Q, Li Y F, Zhang J H. Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression [J]. FEBS Journal, 2016, 283(24):4462-4473.

57.Xing L, Liu Z, Deng G, Wang H, Zhu Y, Shi P, Huo B, Li Y. Xanthogranulomatous prostattis with prostato-rectal fistula:a case report and revew of the literature[J]. Research and Repores in Urology, 2016, 8:165-168.

专利

1.发明专利：CD44v9蛋白在胃癌诊断和预后中的用途，2024你，发明人：刘艳坤、;卢琳、王笑菲、;李景武、;王志武、李青科

2.实用新型专利：BAZ1B_K426hy及其多克隆抗体在制备检测肿瘤的产品中的应用，2023年，发明人：李景武、李玉凤、王淑青

3.日本发明专利：一种人LINE 转座子DNA 甲基化的ICON 探针、检测试剂盒和应用，2023年，发明人：李玉凤、李景武、王磊

4.实用新型专利：一种癌细胞检测用病理切片装置，2021年，发明人：刘艳坤、李玉凤、王磊

二)获奖科技成果

1.应用基础研究，河北医学科技奖一等奖，NHE1抑制剂、circ-AHCY及lnc-DLK1-35对GBM细胞增殖及耐药的影响及机制研究，李玉辉，李景武，刘永亮，孙明阳，李丹，唐山市人民医院

2.应用基础研究，河北医学科技奖一等奖，监测血清HE4评估肺癌化疗及靶向用药疗效的价值研究，张玉敏，翟丽静，李玉柱，高秀娟，鞠思敏，唐山市人民医院

3.应用基础研究，河北医学科技奖一等奖，能谱CT及人附睾丸蛋白4在肺癌疗效监测中的应用价值，李玉柱，张玉敏，肖建波，陈大鹏，张小楠，唐山市人民医院

4.应用基础研究，河北医学科技奖一等奖，基因多态性与乳腺癌发病及药物耐药的关系，蔡海峰 胡万宁 闫金银 沈江伦 路延芹，唐山市人民医院

5.应用基础研究，河北医学科技奖一等奖，乳腺癌MRI表现与白介素-11及其受体、STAT3相关性的研究，李玉柱 韩龙才 张华 刘新唐 张海军，唐山市人民医院

63.应用基础研究，河北医学科技奖一等奖，胸部肿瘤发生与转移过程中microRNAs标志物研究与应用，孙国贵，高鹏，左方，张超，曹春晓，唐山市人民医院

7.应用基础研究，河北医学科技奖二等奖，NHE1在胶质瘤中的表达和活性调节机制及意义的研究，李玉辉 石文建 赵喜庆 李玉凤 刘岩，唐山市人民医院

8.应用基础研究，河北省科技进步二等奖，Mfn2、CBP等肿瘤标志物在乳腺癌、肝癌等肿瘤诊疗中的应用，张景华 刘岩 李玉凤 胡万宁 胡继卫 刘艳坤 盛树海 姜广建 王雅琪 薛书霞

9.应用基础研究，河北医学科技奖一等奖，联合应用药物对治疗恶性胸腹水的临床观察，刘素艳 王帅 常娜 李艳艳 佟玲，唐山市人民医院

10.应用基础研究，河北省科技进步一等奖，肿瘤分子诊疗关键技术研究及应用，孙国贵、胡万宁、李玉凤、张景华、韩晓晨、刘岩、张钧、何喜、程云杰、路一芳

11.应用基础研究，河北省科技进步三等奖，星状神经节阻滞治疗乳腺癌术后并发症的基础与临床研究，蔡海峰、闫金银、侍鹏举、张扬、路延芹

12.应用基础研究，唐山市科技进步二等奖，Cmet，HER2，EGFR，IGF-1R晚期胃癌表达及意义，赵郁、王轶楠、李海丽、朱晓婷、王钧、肖建波、刘金慧、陈莹、高秀娟

13.应用基础研究，河北医学科技奖二等奖，探索有关因子在宫颈癌上皮内瘤变及宫颈癌中的表达及意义，魏璇、郭兴巧、杜雪、马雪梅、刘建荣

14.应用基础研究，河北医学科技奖二等奖，天晴甘平对血液病化疗肝损害疗效及对细胞因子表达研究，刘东芳、赵晓亮、郑雅珍、刘欣、甘静

15.应用基础研究，河北医学科技奖二等奖，TRAIL、FLIP、蛋白在人骨肉瘤中表达及肿瘤细胞增殖和凋亡的关系，付文娟、孙芳初、王连立、郭静、董桂兰

16.应用基础研究，河北医学科技奖二等奖，团体心理治疗对乳腺癌患者生活质量和情绪的影响，李秀玲、徐建国

17.应用基础研究，河北医学科技奖三等奖，P53基因和UGT1A1基因在肺癌患者中的表达及应用，王晓红、刘东芳、姚淑晖、赵洪焕、张晓斌

18.应用基础研究，河北医学科技奖三等奖，P53基因并同期放化疗局部晚期非小细胞肺癌疗效观察，杨俊泉、张晓斌、赵洪焕、李国欢、王翠兰

19.应用基础研究，河北省中医药学会科技奖一等奖，柴胡加龙骨牡蛎汤加减方治疗肿瘤后抑郁的临床研究，王锦辉、王清贤、王建华、张璐、张丽敏、王翠君、柳静、陈淑媛、杨俊泉

20.应用基础研究，河北省中医药学会科技奖二等奖，基于中西医多模态信息构建放射性肺损伤预测模型，王志武、王静怡、胡健、杨俊泉、邢影、房丽、张宪辉

21.应用基础研究，河北省科技进步二等奖，MnSOD等六种基因表达与六种肿瘤恶性表型形成干预的相关研究，胡万宁、孙国贵等

22.应用基础研究，河北医学科技奖一等奖，蒜素衍生物对胃癌治疗作用的体内体外实验研究，闫金银、李骥、韩龙才、胡万宁、李宁

23.应用基础研究，河北医学科技奖一等奖，Mfn2对人乳腺癌裸鼠移植瘤血管表皮生长因子受体(EGFR)影响的研究，张景华、胡继卫、马杰、胡万宁、张顺礼

24.应用基础研究，河北医学科技奖一等奖，个性化干预对不同部位肿瘤患者疼痛及生活质量的影响，王建华、王锦辉、赵凯、王宇、刘春秋

25.应用基础研究，河北医学科技奖一等奖，肺癌患者念珠菌药物敏感性的研究及其分子流行病学特点，张玉敏、李玉柱、马荣芬、陈晖、张尊

26.应用基础研究，河北医学科技奖二等奖，KDR和AQP1在非小细胞肺癌中的表达及意义，张风林、袁亚军、付英霞、张静、张振安

27.应用基础研究，河北医学科技奖二等奖，非霍奇金淋巴瘤NF-KB、蛋白酶体的表达及相关研究，肖建波、李海丽、王学静、王钧、刘金慧

28.应用基础研究，河北医学科技奖二等奖，放化同期治疗对放疗过程中肿瘤再修复再增殖的影响，王轶楠、赵郁、肖建波、李海丽、岳海淑

29.应用基础研究，省中医药学会技术二等奖，鸦胆子油乳对肺癌脑转移的疗效观察及认知功能的影响，王晓红、李义慧、郑国红、佟玲、肖磊、杨俊泉、王建功、黄晓智